Arash Alizadeh Yegani, Hamidreza Alipour Kheirkhah, Ahmad Ostovar, Vahid Koohi, Özge Öztürk
Department of Pharmacology, University of Çukurova, , Adana, Turkey
College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Key words: Diabetes, Alloxan, Honey, Serum parameters, Rat.
Diabetes mellitus is a metabolic disorder in human and animal, particularly in pets. This study is conducted to evaluate the effect of Honey on serum levels of glucose, triglyceride, cholesterol, VLDL, LDL and HDL in experimental diabetes mellitus in rat. Male Wistar rats randomly allocated in four groups: normal, honey control, diabetic control and diabetic rats receiving honey. For creation of diabetes, a single dose of Alloxan (100 mg/kg) injected subcutaneously. After observing diabetes symptoms in groups received Alloxan, we have initiated to feed treatment group and diabetic treatment group with the equal ratio of honey and pellet. The diabetic control and control group fed only with pellet. These groups fed for 10 days. Blood samples collected from whole groups at the end of 10th day. Evaluation of the serum levels of glucose, cholesterol and LDL significantly increased between diabetic group with control group and also between treatment group and diabetic treatment group with diabetic Evaluation of the serum levels of triglyceride did not reveal statistically significant differences in diabetic treatment group and treatment group with control group, but decreased significantly compared to the diabetic control group (P<0.05). Evaluation of the serum Levels of VLDL decreased significantly in diabetic treatment group and treatment group compared with the diabetic control group (P<0.05), but did not reveal statistically difference compared with the control group. Evaluation of the serum levels of HDL did not reveal statistically significant difference between groups. Honey could be used as a natural drug for preventing diabetes mellitus disorders.
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