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Influence of the CYP1B1 gene polymorphisms and uterine leiomyoma risk in Iranian women

Mojdeh Sedighi, Shima Karimnejad, Batol Farhadi, Morteza Hashemzadeh Chaleshtori, Masoud Amiri, Sepideh Miraj

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Social Health Determinants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Deparmment of Obstetrics of Gynecology,Hajar Hospital, Shahrekord University of Medical Sciences,,Shahrekord, Iran

Key words: Leiomyoma, polymorphism, CYP1B1, genotype.

Abstract

detail-uterine-fibroids-14DF1E61BC349DE6D79Uterine leiomyoma (UL) is the most common gynecological benign tumor with unknown etiology and pathogenesis. This case- control study was performed to investigate the association between CYP1B1gene polymorphisms with uterine leiomyoma in Iranian women. Polymorphisms CYP1B1 Arg48Gly, Ala119Ser, Leu432Val and Asp449Asp were genotyped by using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method in 300 premenopausal women with diagnosed UL (cases) and 200 healthy normal (controls). A significant difference was found for the C allele frequencies of the Leu432Val C>G polymorphism between the two groups (OR = 0.71, P = 0.04, 95 % CI = 0.48 – 1.03). However, no significant difference was found for the CYP1B1 Arg48Gly, Ala119Ser and Asp449Asp polymorphisms between the two groups (p>0.05). Our findings indicated that CYP1B1 Leu432Val CC genotype may be involved in susceptibility to UL in Iranian women.

Get the original articles: http://www.innspub.net/volume-6-number-4-february-2015-ijb/

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