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Study of teratologic occurrence in neonatal rat skeletal system under the effect of zonisamide and sodium valproate

H.Erik-Aghaji, H. Gilanpour, S. Hejazi

1Resident of Anatomical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

2Department of Anatomy, Science and Research Branch, Islamic Azad University, Tehran, Iran

3Department of Anatomy, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Key words: Neonatal rat, Skeletal system, Sodium valproate, zonisamide.

Abstract

anxiety-digestion-rat-public-NeurosicenceNEwsAccordingly, in this study, the effects of teratology on a fetal rat skeletal system that received zunsyamide and valproate sodium were evaluated. In conjunction with zonisamide teratogenic effects on the fetus during pregnancy, there is not much information available. High dose of zonisimide (200 mg / kg) was gavaged by animal feeding method to the first intervention group on the ninth and twelfth days of gestation , 600 mg / kg of Sodium valproate was gavaged by animal feeding method (to the second intervention group on the ninth and twelfth days of gestation. The rats in the control group received normal saline on the same days. After the conception, all born babies were kept in an ethanol alcohol solution 96 °. In order to study the newborn’s skeleton system, the red alizarin staining method was used. The obtained data were expressed as Mean ± SEM and analyzed using the ANOVA method. The Abnormalities of Wavy Rib, Abnormal position , scoliosis, and the deviation of the femur and fibula were observed. The position of the sternum and tail vertebrae were normal .Generally, the use of sodium valproate and zonisamide in the ninth to twelfth day of gestation and causes growth disorder in fetus such that creates the reducing impacts in the growth parameters of newborn rats. The use of zonisamide during pregnancy can be considered as a risk factor for the development of newborn that its consumption during organogenesis can cause malformations in the newborn rat.

Get the original articles: http://www.innspub.net/volume-6-number-3-february-2015-ijb/

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